Crystallization, Structural Determination and Structure Modeling
Publications
Udi Y., Grossman M., Solomonov I., Dym O., Rozenberg H., Moreno V., Cuniasse P., Dive V., Arroyo A. G. & Sagi I. (2015).
Inhibition mechanism of membrane metalloprotease by an exosite-swiveling conformational antibody.Structure.2015 Jan 6
,
23
(1):104-115.
Sela-Passwell N. A., Kikkeri R., Dym O., Rozenberg H., Margalit R., Arad-Yellin R., Eisenstein M., Brenner O., Shoham T., Danon T., Shanzer A. & Sagi I. (2012).
Antibodies targeting the catalytic zinc complex of activated matrix metalloproteinases show therapeutic potential.Nature Medicine.2012 Jan
,
18
(1):143-147.
Karanicolas J., Com J. E., Chen I., Joachimiak L. A., Dym O., Peck S. H., Albeck S., Unger T., Hu W., Liu G., Delbecq S., Montelione G. T., Spiegel C. P., Liu D. R. & Baker D. (2011).
A De Novo Protein Binding Pair By Computational Design and Directed Evolution.Molecular Cell.2011 Apr 22
,
42
(2):250-260.
Li M., Greenblatt H. M., Dym O., Albeck S., Pais A., Gunanathan C., Milstein D., Degani H. & Sussman J. (2011).
Structure of estradiol metal chelate and estrogen receptor complex: The basis for designing a new class of selective estrogen receptor modulators.Journal of Medicinal Chemistry.2011 May 26
,
54
(10):3575-3580.
Khersonsky O., Röthlisberger D., Dym O., Albeck S., Jackson C. J., Baker D. & Tawfik D. S. (2010).
Evolutionary optimization of computationally designed enzymes: Kemp eliminases of the ke07 series.Journal of Molecular Biology.2010,
396
(4):1025-1042.
Grossman M., Tworowski D., Dym O., Lee M., Levy Y., Murphy G. & Sagi I. (2010).
The intrinsic protein flexibility of endogenous protease inhibitor TIMP-1 controls its binding interface and affects its function.Biochemistry.2010 Jul 27
,
49
(29):6184-6192.
Goihberg E., Peretz M., Tel-Or S., Dym O., Shimon L., Frolow F. & Burstein Y. (2010).
Biochemical and structural properties of chimeras constructed by exchange of cofactor-binding domains in alcohol dehydrogenases from thermophilic and mesophilic microorganisms.Biochemistry.2010 Mar 9
,
49
(9):1943-1953.
Dym O., Albeck S., Peleg Y., Schwarz A., Shakked Z., Burstein Y. & Zimhony O. (2009).
Structure-Function Analysis of the Acyl Carrier Protein Synthase (AcpS) from Mycobacterium tuberculosis.Journal of Molecular Biology.2009 Nov 6
,
393
(4):937-950.
Liberman N., Dym O., Unger T., Albeck S., Peleg Y., Jacobovitch Y., Branzburg A., Eisenstein M., Marash L. & Kimchi A. (2008).
The Crystal Structure of the C-Terminal DAP5/p97 Domain Sheds Light on the Molecular Basis for Its Processing by Caspase Cleavage.Journal of Molecular Biology.2008 Nov 14
,
383
(3):539-548.
Albeck S., Dym O., Unger T., Snapir Z., Bercovich Z. & Kahana C. (2008).
Crystallographic and biochemical studies revealing the structural basis for antizyme inhibitor function.Protein Science.2008 May
,
17
(5):793-802.