Targeted Metabolomics Publications

  1. Adsi H., Gartner M., Simovich C., Gershon L., Brandis A., Gazit E. & Laor Bar-Yosef D. (2026). Shikimate pathway disruption in yeast induces metabolite self-assembly into toxic aggregates.  FEBS Journal. 2026 Feb 3 , .
  2. Tishler H., Ziman S., Cheng K., Wang K., Sanghvi N., Adler L., Stelzer G., Maniriho H., Dassa B., Bab-Dinitz E., Levi M., Galai S., Goldman O., Ariav Y., Darzi N., Ezagouri S., Nimni N., Rosenfeld N., Rotkopf R., Brandis A., Mehlman T., Oren R., Zerbib M., Kuznetsov Y., Donzelli S., Blandino G., Seger R., Ruppin E. & Erez A. (2026). Inhibition of Tumor Microenvironment-Driven JAK-STAT Signaling Enhances Response to Arginine Deprivation Therapy in Triple-Negative Breast Cancer.  Cells. 2026 Jan , 15 (1).
  3. Tishler H., Ziman S., Cheng K., Wang K., Sanghvi N., Adler L., Stelzer G., Maniriho H., Dassa B., Bab-Dinitz E., Levi M., Galai S., Goldman O., Ariav Y., Darzi N., Ezagouri S., Nimni N., Rosenfeld N., Rotkopf R., Brandis A., Mehlman T., Oren R., Zerbib M., Kuznetsov Y., Donzelli S., Blandino G., Seger R., Ruppin E. & Erez A. (2026). Inhibition of Tumor Microenvironment-Driven JAK-STAT Signaling Enhances Response to Arginine Deprivation Therapy in Triple-Negative Breast Cancer.  Cells. 2026 Jan , 15 (1).
  4. Laue K., Pozzi S., Zerbib J., Bertolio R., Eliezer Y., Cohen-Sharir Y., Winkler T., Caputo M., Ricci A. A., Adler L., Khoury R., Longobardi G., Slutsky R., Leikin-Frenkel A. I., Ovadia S., Lange K., Rustighi A., Piazza S., Sacconi A., Magesh R. Y., Keller F. N., Berthelet J., Schäffer A., Saad R., Israeli Dangoor S., Szczepanowska K., Barshack I., Liao Y., Malitsky S., Brandis A., Broggini T., Czabanka M., Shi W., Merino D., Watson E. V., Blandino G., Erez A., Ashery-Padan R., Medyouf H., Bertero L., Del Sal G., Satchi-Fainaro R. & Ben-David U. (2026). p53 inactivation drives breast cancer metastasis to the brain through SCD1 upregulation and increased fatty acid metabolism.  Nature Genetics. 2026 Jan , 58 (1):116-131.
  5. Vogels D. H., Brekelmans J., Mohren R., Vos N. R., Brandis A., Marcovich A. L., Cillero-Pastor B., Scherz A., LaPointe V. L. & Dickman M. M. (2025). Proteomics Reveals Mechanisms of Delayed Keratoconus Progression: A Study of Corneas Following Two Light-Activated Crosslinking Treatments.  Investigative Ophthalmology and Visual Science. 2025 Jan , 66 (1).
  6. Vogels D. H. J., Brekelmans J., Mohren R., Vos N. R. N., Brandis A., Marcovich A. L., Cillero-Pastor B., Scherz A., LaPointe V. L. S. & Dickman M. M. (2025). Proteomics reveals mechanisms of delayed keratoconus progression: A study of corneas following two light-activated crosslinking treatments.  Acta Ophthalmologica. 2025 Apr , 103 (S285).
  7. Kesler Y. M., Kviatkovski I., Rotem N., Brandis A., Shoseyov O., Yarnitzky T. & Helman Y. (2025). Detection of Spoilage-Associated Acetic Acid Levels Using a Transcription-Based Whole-Cell Biosensor.  Microbial Biotechnology. 2025 Dec , 18 (12).
  8. Chourasia S., Petucci C., Shoffler C., Abbasian D., Wang H., Han X., Sivan E., Brandis A., Mehlman T., Malitsky S., Itkin M., Sharp A., Rotkopf R., Dassa B., Regev L., Zaltsman Y. & Gross A. (2025). MTCH2 controls energy demand and expenditure to fuel anabolism during adipogenesis.  EMBO Journal. 2025 Feb 17 , 44 (4):1007-1038.
  9. Chourasia S., Petucci C., Shoffler C., Abbasian D., Wang H., Han X., Sivan E., Brandis A., Mehlman T., Malitsky S., Itkin M., Sharp A., Rotkopf R., Dassa B., Regev L., Zaltsman Y. & Gross A. (2025). MTCH2 controls energy demand and expenditure to fuel anabolism during adipogenesis.  EMBO Journal. 2025 Feb 17 , 44 (4):1007-1038.
  10. Garrett A., Darzi N., Deshmukh A., Rosenfeld N., Goldman O., Adler L., Bab-Dinitz E., Singer O., Hassani Najafabadi A., Wong C. W., Bose S., Randon P. M., Bustamante F., Larios R., Brandis A., Mehlman T., Smaglo B., Chang P., Oliva J., Haymaker C., Nagawekar L., Wu S. R., Huang Y., Shen A., Vora A., Padilla J. F., Pfeffer A., Sutherland G., Starr M., Zimmers T., Zhu Y., Morizio J., Erez A. & Shen X. (2025). Vagal blockade of the brain-liver axis deters cancer-associated cachexia.  Cell. 2025 Oct 16 , 188 (21):6044-6063.e24.
  11. Zahavi E. E., Rishal I., Oses-Prieto J. A., Brandis A., Malitsky S., Itkin M., Pokorná Š., Cabrera-Cabrera F., Seeba N. N., Risti R., Lõokene A., Futerman A. H., Burlingame A. L., Fainzilber M. & Koppel I. (2025). Nucleolin perturbation alters membrane lipid homeostasis.  Molecular Omics. 2025 Nov 1 , 21 (6):723-735.
  12. Furth N., Cohen N., Spitzer A., Salame T. M., Dassa B., Mehlman T., Brandis A., Moussaieff A., Friedmann-Morvinski D., Castro M. G., Fortin J., Suvà M. L., Tirosh I., Erez A., Ron G. & Shema E. (2025). Oncogenic IDH1mut drives robust loss of histone acetylation and increases chromatin heterogeneity.  Proceedings of the National Academy of Sciences - PNAS. 2025 Jan 7 , 122 (1).
  13. Sibony-Benyamini H., Jbara R., Shubash Napso T., Abu-Rahmoun L., Vizenblit D., Easton-Mor M., Perez S., Brandis A., Leshem T., Peretz A. & Maman Y. (2025). The landcape of Helicobacter pylori-mediated DNA breaks links bacterial genotoxicity to its oncogenic potential.  Genome Medicine. 2025 Dec , 17 (1).
  14. Garrett A., Darzi N., Deshmukh A., Rosenfeld N., Goldman O., Adler L., Bab-Dinitz E., Singer O., Hassani Najafabadi A., Wong C. W., Bose S., Randon P. M., Bustamante F., Larios R., Brandis A., Mehlman T., Smaglo B., Chang P., Oliva J., Haymaker C., Nagawekar L., Wu S. R., Huang Y., Shen A., Vora A., Padilla J. F., Pfeffer A., Sutherland G., Starr M., Zimmers T., Zhu Y., Morizio J., Erez A. & Shen X. (2025). Vagal blockade of the brain-liver axis deters cancer-associated cachexia.  Cell. 2025 Oct 16 , 188 (21):6044-6063.e24.
  15. Passini F. S., Bornstein B., Rubin S., Kuperman Y., Krief S., Masschelein E., Mehlman T., Brandis A., Addadi Y., Shalom S. H. O., Richter E. A., Yardeni T., Tirosh A., De Bock K. & Zelzer E. (2025). Piezo2 in sensory neurons regulates systemic and adipose tissue metabolism.  Cell Metabolism. 2025 Apr 1 , 37 (4):987-1000.e6.
  16. Furth N., Cohen N., Spitzer A., Salame T. M., Dassa B., Mehlman T., Brandis A., Moussaieff A., Friedmann-Morvinski D., Castro M. G., Fortin J., Suvà M. L., Tirosh I., Erez A., Ron G. & Shema E. (2025). Oncogenic IDH1mut drives robust loss of histone acetylation and increases chromatin heterogeneity.  Proceedings of the National Academy of Sciences - PNAS. 2025 Jan 7 , 122 (1).
  17. Passini F. S., Bornstein B., Rubin S., Kuperman Y., Krief S., Masschelein E., Mehlman T., Brandis A., Addadi Y., Shalom S. H. O., Richter E. A., Yardeni T., Tirosh A., De Bock K. & Zelzer E. (2025). Piezo2 in sensory neurons regulates systemic and adipose tissue metabolism.  Cell Metabolism. 2025 Apr 1 , 37 (4):987-1000.e6.
  18. Goldsmith M., Avram L., Brandis A., Mehlman T., Ben-Dor S., Peleg Y., Ben-Zeev E., Barbole R. S. & Reich Z. (2024). LsBOS utilizes oxalyl-CoA produced by LsAAE3 to synthesize β-ODAP in grass pea.  Nature Communications. 2024 Dec , 15 (1).
  19. Allouche-Arnon H., Montrazi E. T., Subramani B., Fisler M., Spigel I., Frydman L., Mehlman T., Brandis A., Harris T. & Bar-Shir A. (2024). A Genetically Engineered Reporter System Designed for 2H-MRI Allows Quantitative In Vivo Mapping of Transgene Expression.  Journal of the American Chemical Society. 2024 Nov 20 , 146 (46):31624-31632.
  20. Lim L. Q. J., Adler L., Hajaj E., Soria L. R., Perry R. B. T., Darzi N., Brody R., Furth N., Lichtenstein M., Bab-Dinitz E., Porat Z., Melman T., Brandis A., Malitsky S., Itkin M., Aylon Y., Ben-Dor S., Orr I., Pri-Or A., Seger R., Shaul Y., Ruppin E., Oren M., Perez M., Meier J., Brunetti-Pierri N., Shema E., Ulitsky I. & Erez A. (2024). ASS1 metabolically contributes to the nuclear and cytosolic p53-mediated DNA damage response.  Nature metabolism. 2024 Jul , 6 (7):1294-1309.