Crystallization, Structural Determination and Structure Modeling
Publications
Suzumoto Y., Dym O., Roviello G. N., Worek F., Sussman J. L. & Manco G. (2020).
Structural and functional characterization of new ssopox variant points to the dimer interface as a driver for the increase in promiscuous paraoxonase activity.International Journal of Molecular Sciences.2020 Mar 1
,
21
(5).
Warszawski S., Katz A. B., Lipsh R., Khmelnitsky L., Nissan G. B., Javitt G., Dym O., Unger T., Knop O., Albeck S., Diskin R., Fass D., Sharon M. & Fleishman S. J. (2020).
Erratum: Optimizing antibody affinity and stability by the automated design of the variable light-heavy chain interfaces (PLoS Computational Biology(2019)15: 8(e1007207)Doi: 10.1371/journal.pcbi.1007207).PLoS Computational Biology.2020 Oct 21
,
16
(10).
Ben-David M., Soskine M., Dubovetskyi A., Cherukuri K., Dym O., Sussman J. L., Liao Q., Szeler K., Kamerlin S. C. L. & Tawfik D. S. (2020).
Enzyme Evolution: An Epistatic Ratchet versus a Smooth Reversible Transition.Molecular Biology and Evolution.2020 Apr
,
37
(4):1133-1147.
Novichkova D. A., Lushchekina S., Dym O., Masson P., Silman I. & Sussman J. L. (2019).
The four-helix bundle in cholinesterase dimers: Structural and energetic determinants of stability.Chemico-Biological Interactions.2019 Aug 25
,
309
.
Arafeh R., Di Pizio A., Elkahloun A. G., Dym O., Niv M. Y. & Samuels Y. (2019).
RASA2 and NF1; two-negative regulators of Ras with complementary functions in melanoma.Oncogene.2019 Mar 28
,
38
(13):2432-2434.
Warszawski S., Katz A. B., Lipsh R., Khmelnitsky L., Ben Nissan G., Javitt G., Dym O., Unger T., Knop O., Albeck S., Diskin R., Fass D., Sharon M. & Fleishman S. J. (2019).
Optimizing antibody affinity and stability by the automated design of the variable light-heavy chain interfaces.PLoS Computational Biology.2019 Aug 23
,
15
(8).
Netzer R., Listov D., Lipsh R., Dym O., Albeck S., Knop O., Kleanthous C. & Fleishman S. J. (2018).
Ultrahigh specificity in a network of computationally designed protein-interaction pairs.Nature Communications.2018 Dec 11
,
9
(1).
Lapidoth G., Khersonsky O., Lipsh R., Dym O., Albeck S., Rogotner S. & Fleishman S. J. (2018).
Highly active enzymes by automated combinatorial backbone assembly and sequence design.Nature Communications.2018 Jul 17
,
9
.
Khersonsky O., Lipsh R., Avizemer Z., Ashani Y., Goldsmith M., Leader H., Dym O., Rogotner S., Trudeau D. L., Prilusky J., Amengual-Rigo P., Guallar V., Tawfik D. S. & Fleishman S. J. (2018).
Automated Design of Efficient and Functionally Diverse Enzyme Repertoires.Molecular Cell.2018 Oct 4
,
72
(1):178-186.e5.
Ben-Nissan G., Belov M. E., Morgenstern D., Levin Y., Dym O., Arkind G., Lipson G., Makarov A. A. & Sharon M. (2017).
Triple-Stage Mass Spectrometry Unravels the Heterogeneity of an Endogenous Protein Complex.Analytical Chemistry.2017 Apr 18
,
89
(8):4708-4715.
Dym O., Song W., Felder C., Roth E., Shnyrov V., Ashani Y., Xu Y., Joosten R. P., Weiner L., Sussman J. & Silman I. (2016).
The impact of crystallization conditions on structure-based drug design: A case study on the methylene blue/acetylcholinesterase complex.Protein Science.2016 Jun 1
,
25
(6):1096-1114.
Goldenzweig A., Goldsmith M., Hill S. E., Gertman O., Laurino P., Ashani Y., Dym O., Unger T., Albeck S., Prilusky J., Lieberman R. L., Aharoni A., Silman I., Sussman J., Tawfik D. & Fleishman S. J. (2016).
Automated Structure- and Sequence-Based Design of Proteins for High Bacterial Expression and Stability.Molecular Cell.2016 Jul 21
,
63
(2):337-346.
Smock R. G., Yadid I., Dym O., Clarke J. & Tawfik D. (2016).
De Novo Evolutionary Emergence of a Symmetrical Protein Is Shaped by Folding Constraints.Cell.2016 Jan 28
,
164
(3):476-486.
Udi Y., Grossman M., Solomonov I., Dym O., Rozenberg H., Moreno V., Cuniasse P., Dive V., Arroyo A. G. & Sagi I. (2015).
Inhibition mechanism of membrane metalloprotease by an exosite-swiveling conformational antibody.Structure.2015 Jan 6
,
23
(1):104-115.