Research

Pioneering enabling technologies to decode the epiProteome

Our lab is at the forefront of epiProteome research, leveraging an interdisciplinary approach that integrates biochemistry, cell biology, proteomics, and computational tools to develop cutting-edge technologies. We have pioneered three transformative platform technologies that allow us to systematically dissect the regulatory landscape of protein modifications and degradation dynamics in cancer and immune-related diseases

Uncovering epiProteome Regulation in Health & Disease

Our lab explores how post-translational modifications and proteasome dynamics regulate cellular identity, immunity, and disease progression. Our recent studies have uncovered key molecular mechanisms shaping epigenetic and proteostatic landscapes in various biological contexts.

Developing epiProteome-based Therapeutics

Our lab aims to translate our findings to impact human health. We are pioneering novel therapeutic solutions by harnessing epiProteome regulation mechanisms at multiple levels—protein modification, degradation pathways, and the functional roles of proteolytic peptides. By integrating these layers of control, we aim to unlock new treatments for a wide range of human diseases.