Research

Senescence in aging & age-related diseases

Senescent cells accumulate in the organism with age, contributing to age-related diseases and aging. We study the role of senescent cells in age-related lung, liver, and neurodegenerative diseases. We discover the mechanisms that regulate the accumulation of senescent cells in these diseases. These mechanisms provide new targets for their treatment.

Senescence in cancer development and anti-cancer therapy

Cellular senescence, which is a terminal cell cycle arrest, is a potent tumor suppressor mechanism that limits cancer initiation and progression.

Interaction of senescent cells with the immune system

We study the mechanisms of interaction of senescent cells with immune cells and harness these mechanisms for the elimination of senescent cells. We have discovered mechanisms of interaction of senescent cells with components of both innate and adaptive immune systems.