Publications

2024

SRF transcriptionally regulates the oligodendrocyte cytoskeleton during CNS myelination

Iram T., Garcia M. A., Amand J., Kaur A., Atkins M., Iyer M., Lam M., Ambiel N., Jorgens D. M., Keller A., Wyss-Coray T., Kern F. & Zuchero J. B. (2024) Proceedings of the National Academy of Sciences of the United States of America. 121, 12, e230725012.

2023

A protocol for collection and infusion of cerebrospinal fluid in mice

Kaur A., Shuken S., Yang A. C. & Iram T. (2023) STAR Protocols. 4, 1, 102015.

2022

SRF transcriptionally regulates the oligodendrocyte cytoskeleton during CNS myelination

Iram T., Garcia M. A., Amand J., Kaur A., Iyer M., Lam M., Ambiel N., Keller A., Wyss-Coray T., Kern F. & Zuchero J. B. (2022) BioRxiv.

Young CSF restores oligodendrogenesis and memory in aged mice via Fgf17

Iram T., Kern F., Kaur A., Myneni S., Morningstar A. R., Shin H., Garcia M. A., Yerra L., Palovics R., Yang A. C., Hahn O., Lu N., Shuken S. R., Haney M. S., Lehallier B., Iyer M., Luo J., Zetterberg H., Keller A., Zuchero J. B. & Wyss-Coray T. (2022) Nature. 605, 7910, p. 509-515

Limited proteolysismass spectrometry reveals aging-associated changes in cerebrospinal fluid protein abundances and structures

Shuken S. R., Rutledge J., Iram T., Losada P. M., Wilson E. N., Andreasson K. I., Leib R. D. & Wyss-Coray T. (2022) Nature Aging. 2, 5, p. 379-388

Molecular hallmarks of heterochronic parabiosis at single-cell resolution

Pálovics R., Keller A., Schaum N., Tan W., Fehlmann T., Borja M., Kern F., Bonanno L., Calcuttawala K., Webber J., McGeever A., Almanzar N., Antony J., Baghel A. S., Bakerman I., Bansal I., Barres B. A., Beachy P. A., Berdnik D., Bilen B. & Iram T. (2022) Nature. 603, 7900, p. 309-314

2021

The CD22-IGF2R interaction is a therapeutic target for microglial lysosome dysfunction in Niemann-Pick type C

Pluvinage J. V., Sun J., Claes C., Flynn R. A., Haney M. S., Iram T., Meng X., Lindemann R., Riley N. M., Danhash E., Chadarevian J. P., Tapp E., Gate D., Kondapavulur S., Cobos I., Chetty S., Paşca A. M., Paşca S. P., Berry-Kravis E., Bertozzi C. R., Blurton-Jones M. & Wyss-Coray T. (2021) Science Translational Medicine. 13, 622, abg2919.

2020

A single-cell transcriptomic atlas characterizes ageing tissues in the mouse

Almanzar N., Antony J., Baghel A. S., Bakerman I., Bansal I., Barres B. A., Beachy P. A., Berdnik D., Bilen B., Brownfield D., Cain C., Chan C. K., Chen M. B., Clarke M. F., Conley S. D., Darmanis S., Demers A., Demir K., de Morree A., Divita T. & Iram T. (2020) Nature. 583, 7817, p. 590-595

Ageing hallmarks exhibit organ-specific temporal signatures

Schaum N., Lehallier B., Hahn O., Pálovics R., Hosseinzadeh S., Lee S. E., Sit R., Lee D. P., Losada P. M., Zardeneta M. E., Fehlmann T., Webber J. T., McGeever A., Calcuttawala K., Zhang H., Berdnik D., Mathur V., Tan W., Zee A., Tan M. & Iram T. (2020) Nature. 583, 7817, p. 596-602

Physiological bloodbrain transport is impaired with age by a shift in transcytosis

Yang A. C., Stevens M. Y., Chen M. B., Lee D. P., Stähli D., Gate D., Contrepois K., Chen W., Iram T., Zhang L., Vest R. T., Chaney A., Lehallier B., Olsson N., du Bois H., Hsieh R., Cropper H. C., Berdnik D., Li L., Wang E. Y., Traber G. M., Bertozzi C. R., Luo J., Snyder M. P., Elias J. E., Quake S. R., James M. L. & Wyss-Coray T. (2020) Nature. 583, 7816, p. 425-430

Lipid-droplet-accumulating microglia represent a dysfunctional and proinflammatory state in the aging brain

Marschallinger J., Iram T., Zardeneta M., Lee S. E., Lehallier B., Haney M. S., Pluvinage J. V., Mathur V., Hahn O., Morgens D. W., Kim J., Tevini J., Felder T. K., Wolinski H., Bertozzi C. R., Bassik M. C., Aigner L. & Wyss-Coray T. (2020) Nature Neuroscience. 23, 2, p. 194-208

2019

Single-cell analysis of cytoskeleton dynamics: From isoelectric focusing to live cell imaging and RNA-seq

Gozes I., Ivashko-Pachima Y., Kapitansky O., Sayas C. L. & Iram T. (2019) Journal of Neuroscience Methods. 323, p. 119-124

Astrocyte senescence in an Alzheimers disease mouse model is mediated by TGF-β1 and results in neurotoxicity

Amram S., Iram T., Lazdon E., Vassar R., Ben-Porath I. & Frenkel D. (2019) BioRxiv.

An 80,000-Piece Puzzle of Alzheimer's Disease

Iram T., Keller A. & Wyss-Coray T. (2019) Immunity. 50, 6, p. 1349-1351

CD22 blockade restores homeostatic microglial phagocytosis in ageing brains

Pluvinage J. V., Haney M. S., Smith B. A., Sun J., Iram T., Bonanno L., Li L., Lee D. P., Morgens D. W., Yang A. C., Shuken S. R., Gate D., Scott M., Khatri P., Luo J., Bertozzi C. R., Bassik M. C. & Wyss-Coray T. (2019) Nature. 568, 7751, p. 187-192

2018

Single-cell transcriptomics of 20 mouse organs creates a Tabula Muris

Schaum N., Karkanias J., Neff N. F., May A. P., Quake S. R., Wyss-Coray T., Darmanis S., Batson J., Botvinnik O., Chen M. B., Chen S., Green F., Jones R. C., Maynard A., Penland L., Pisco A. O., Sit R. V., Stanley G. M., Webber J. T., Zanini F. & Iram T. (2018) Nature. 562, 7727, p. 367-372

2016

Astrocytes from old Alzheimer's disease mice are impaired in Aβ uptake and in neuroprotection

Iram T., Trudler D., Kain D., Kanner S., Galron R., Vassar R., Barzilai A., Blinder P., Fishelson Z. & Frenkel D. (2016) Neurobiology of Disease. 96, p. 84-94

Nucleolin inhibitor GroA triggers reduction in epidermal growth factor receptor activation: Pharmacological implication for glial scarring after spinal cord injury

Goldshmit Y., Schokoroy Trangle S., Afergan F., Iram T. & Pinkas-Kramarski R. (2016) Journal of Neurochemistry. 138, 6, p. 845-858

Megf10 Is a receptor for C1Q that mediates clearance of apoptotic cells by astrocytes

Iram T., Ramirez-Ortiz Z., Byrne M. H., Coleman U. A., Kingery N. D., Means T. K., Frenkel D. & El Khoury J. (2016) Journal of Neuroscience. 36, 19, p. 5185-5192

Impaired Autophagy in APOE4 Astrocytes

Simonovitch S., Schmukler E., Bespalko A., Iram T., Frenkel D., Holtzman D. M., Masliah E., Michaelson D. M. & Pinkas-Kramarski R. (2016) Journal of Alzheimer's Disease. 51, 3, p. 915-927

2014

Novel tubulin and tau neuroprotective fragments sharing structural similarities with the drug candidate NAP (Davuentide)

Gozes I., Iram T., Maryanovsky E., Arviv C., Rozenberg L., Schirer Y., Giladi E. & Furman-Assaf S. (2014) Journal of Alzheimer's Disease. 40, S1, p. S23-S36

2013

The scavenger receptor SCARF1 mediates the clearance of apoptotic cells and prevents autoimmunity

Ramirez-Ortiz Z. G., Pendergraft W. F., Prasad A., Byrne M. H., Iram T., Blanchette C. J., Luster A. D., Hacohen N., Khoury J. E. & Means T. K. (2013) Nature Immunology. 14, 9, p. 917-926

Plum, an immunoglobulin superfamily protein, regulates axon pruning by facilitating TGF-β signaling

Yu X. M., Gutman I., Mosca T. J., Iram T., Oezkan E., Garcia K. C., Luo L. & Schuldiner O. (2013) Neuron. 78, 3, p. 456-468

2012

Targeting the role of astrocytes in the progression of alzheimer's disease

Iram T. & Frenkel D. (2012) Current Signal Transduction Therapy. 7, 1, p. 20-27