Targeted Metabolomics Publications

  1. Goldsmith M., Avram L., Brandis A., Mehlman T., Ben-Dor S., Peleg Y., Ben-Zeev E., Barbole R. S. & Reich Z. (2024). LsBOS utilizes oxalyl-CoA produced by LsAAE3 to synthesize β-ODAP in grass pea.  Nature Communications. 2024 Aug 8 , 15 .
  2. Brandis A., Roy D., Das I., Sheves M. & Eisenbach M. (2024). Uncommon opsins retinal isomer is involved in mammalian sperm thermotaxis.  Scientific Reports. 2024 May 10 , 14 .
  3. Allouche-Arnon H., Montrazi E. T., Subramani B., Fisler M., Spigel I., Frydman L., Mehlman T., Brandis A., Harris T. & Bar-Shir A. (2024). A Genetically Engineered Reporter System Designed for 2H-MRI Allows Quantitative In Vivo Mapping of Transgene Expression.  Journal of the American Chemical Society. 2024 Nov 20 , 146 (46):31624-31632.
  4. Moraïs S., Mazor M., Tovar-Herrera O., Zehavi T., Zorea A., Ifrach M., Bogumil D., Brandis A., Walter J., Elia N., Gur E. & Mizrahi I. (2024). Plasmid-encoded toxin defence mediates mutualistic microbial interactions.  Nature Microbiology. 2024 Jan , 9 :108-119.
  5. Lim L. Q. J., Adler L., Hajaj E., Soria L. R., Perry R. B. T., Darzi N., Brody R., Furth N., Lichtenstein M., Bab-Dinitz E., Porat Z., Melman T., Brandis A., Aylon Y., Ben-Dor S., Orr I., Pri-Or A., Seger R., Shaul Y., Ruppin E., Oren M., Perez M., Meier J., Brunetti-Pierri N., Shema E., Ulitsky I., Erez A., Malitsky S. & Itkin M. (2024). ASS1 metabolically contributes to the nuclear and cytosolic p53-mediated DNA damage response.  Nature metabolism. 2024 Jul , 6 (7):1294-1309.
  6. Stroganov S., Harris T., Alyagor L., Ben Moyal L., Plitman Mayo R., Golani O., Hirsch D., Ben-Dor S., Brandis A., Mehlman T., Kovo M., Biron-Shental T., Dekel N. & Neeman M. (2024). The differential regulation of placenta trophoblast bisphosphoglycerate mutase in fetal growth restriction: preclinical study in mice and observational histological study of human placenta.  eLife. 2024 Feb 5 , 13 .
  7. Bahat A., Itzhaki E., Weiss B., Tolmasov M., Tsoory M., Kuperman Y., Brandis A., Shurrush K. A. & Dikstein R. (2024). Lowering mutant huntingtin by small molecules relieves Huntingtons disease symptoms and progression.  EMBO Molecular Medicine. 2024 Feb 19 , 16 (3):523-546.
  8. Garb J., Amitai G., Lu A., Ofir G., Brandis A., Mehlman T., Kranzusch P. J. & Sorek R. (2024). The SARM1 TIR domain produces glycocyclic ADPR molecules as minor products.  PLoS ONE. 2024 Apr 18 , 19 (4 ).
  9. Schlichter Kadosh Y., Muthuraman S., Nisaa K., Ben-Zvi A., Karsagi Byron D. L., Shagan M., Brandis A., Mehlman T., Gopas J., Saravana Kumar R. & Kushmaro A. (2024). Pseudomonas aeruginosa quorum sensing and biofilm attenuation by a di-hydroxy derivative of piperlongumine (PL-18).  Biofilm. 2024 Dec , 8 .
  10. Barak-Gavish N., Dassa B., Kuhlisch C., Nussbaum I., Brandis A., Rosenberg G., Avraham R. & Vardi A. (2023). Bacterial lifestyle switch in response to algal metabolites.  eLife. 2023 Jan 24 , 12 .
  11. Rousset F., Yirmiya E., Nesher S., Brandis A., Mehlman T., Itkin M., Malitsky S., Millman A., Melamed S. & Sorek R. (2023). A conserved family of immune effectors cleaves cellular ATP upon viral infection.  Cell. 2023 Aug 17 , 186 (17):3619-3631.e13.
  12. Suzzi S., Croese T., Ravid A., Gold O., Clark A. R., Medina S., Kitsberg D., Adam M., Vernon K. A., Kohnert E., Shapira I., Malitsky S., Itkin M., Brandis A., Mehlman T., Salame T. M., Colaiuta S. P., Cahalon L., Slyper M., Greka A., Habib N. & Schwartz M. (2023). N-acetylneuraminic acid links immune exhaustion and accelerated memory deficit in diet-induced obese Alzheimers disease mouse model.  Nature Communications. 2023 Dec , 14 (1).
  13. Nobs S. P., Kolodziejczyk A. A., Adler L., Horesh N., Botscharnikow C., Herzog E., Mohapatra G., Hejndorf S., Hodgetts R. J., Spivak I., Schorr L., Fluhr L., Kviatcovsky D., Zacharia A., Njuki S., Barasch D., Stettner N., Dori-Bachash M., Harmelin A., Brandis A., Mehlman T., Erez A., He Y., Ferrini S., Puschhof J., Shapiro H., Kopf M., Moussaieff A., Abdeen S. K. & Elinav E. (2023). Lung dendritic-cell metabolism underlies susceptibility to viral infection in diabetes.  Nature. 2023 Dec 21 , 624 (7992):645-652.
  14. Duncan-Lowey B., Tal N., Johnson A. G., Rawson S., Mayer M. L., Doron S., Millman A., Melamed S., Fedorenko T., Kacen A., Brandis A., Mehlman T., Amitai G., Sorek R. & Kranzusch P. J. (2023). Cryo-EM structure of the RADAR supramolecular anti-phage defense complex.  Cell. 2023 Mar 2 , 186 (5):987-998.
  15. Chourasia S., Petucci C., Wang H., Han X., Sivan E., Brandis A., Mehlman T., Malitsky S., Itkin M., Rotkopf R., Regev L., Zaltsman Y. & Gross A. (2023). High-energy demand and nutrient exhaustion in MTCH2 knockout cells.  BioRxiv. 2023 Dec 16 , .
  16. Uzonyi A., Dierks D., Nir R., Kwon O. S., Toth U., Barbosa I., Burel C., Brandis A., Rossmanith W., Le Hir H., Slobodin B. & Schwartz S. (2023). Exclusion of m6A from splice-site proximal regions by the exon junction complex dictates m6A topologies and mRNA stability.  Molecular Cell. 2023 Jan 19 , 83 (2):237-251.e7.
  17. Koh E., Chaturvedi A. K., Javitt G., Brandis A. & Fluhr R. (2023). Multiple paths of plant host toxicity are associated with the fungal toxin cercosporin.  Plant Cell And Environment. 2023 Aug , 46 (8):2542-2557.
  18. Noronha A., Belugali Nataraj N., Sang Lee J., Zhitomirsky B., Oren Y., Oster S., Lindzen M., Mukherjee S., Will R., Ghosh S., Simoni-Nieves A., Verma A., Chatterjee R., Borgoni S., Robinson W., Sinha S., Brandis A., Kerr D. L., Wu W., Sekar A., Giri S., Chung Y., Drago-Garcia D., Danysh B. P., Lauriola M., Fiorentino M., Ardizzoni A., Oren M., Blakely C. M., Ezike J., Wiemann S., Parida L., Bivona T. G., Aqeilan R. I., Brugge J. S., Regev A., Getz G., Ruppin E. & Yarden Y. (2022). AXL and Error-Prone DNA Replication Confer Drug Resistance and Offer Strategies to Treat EGFR-Mutant Lung Cancer.  Cancer Discovery. 2022 Nov 1 , 12 (11):2666-2683.
  19. Goldsmith M., Barad S., Knafo M., Savidor A., Ben-Dor S., Brandis A., Mehlman T., Peleg Y., Albeck S., Dym O., Ben-Zeev E., Barbole R. S., Aharoni A. & Reich Z. (2022). Identification and characterization of the key enzyme in the biosynthesis of the neurotoxin β-ODAP in grass pea.  The journal of Biological chemistry. 2022 May 1 , 298 (5).
  20. Millman A., Melamed S., Leavitt A., Doron S., Bernheim A., Hör J., Garb J., Bechon N., Brandis A., Lopatina A., Ofir G., Hochhauser D., Stokar-Avihail A., Tal N., Sharir S., Voichek M., Erez Z., Ferrer J. L. M., Dar D., Kacen A., Amitai G. & Sorek R. (2022). An expanded arsenal of immune systems that protect bacteria from phages.  Cell Host and Microbe. 2022 Nov 9 , 30 (11):1556-1569e5.