Protein Purification Publications

  1. Sobolev V., Edelman M., Dym O., Unger T., Albeck S., Kirma M. & Galili G. (2013). Structure of ALD1, a plant-specific homologue of the universal diaminopimelate aminotransferase enzyme of lysine biosynthesis.  Acta Crystallographica Section F-Structural Biology And Crystallization Communications. 2013 Feb , 69 (2):84-89.
  2. Hama S., Soran H., Albeck S., Charlton-Menys V., Yadav R., Liu Y., France M., Tawfiq D. & Durrington P. (2012). HIGH PARAOXONASE-1 HDL IS MORE EFFECTIVE THAN LOW PARAOXONASE-1 HDL IN IMPEDING LDL OXIDATION IN VITRO.  Atherosclerosis. 2012 Aug , 223 (2):529-529.
  3. Khersonsky O., Kiss G., Röthlisberger D., Dym O., Albeck S., Houk K. N., Baker D. & Tawfik D. S. (2012). Bridging the gaps in design methodologies by evolutionary optimization of the stability and proficiency of designed Kemp eliminase KE59.  Proceedings of the National Academy of Sciences of the United States of America. 2012 Jun 26 , 109 (26):10358-10363.
  4. Siton O., Ideses Y., Albeck S., Unger T., Bershadsky A. D., Gov N. S. & Bernheim-Groswasser A. (2011). Cortactin releases the brakes in actin- based motility by enhancing WASP-VCA detachment from Arp2/3 branches.  Current Biology. 2011 Dec 20 , 21 (24):2092-2097.
  5. Cohen S., Albeck S., Ben-Dov E., Cahan R., Firer M., Zaritsky A. & Dym O. (2011). Cyt1Aa toxin: Crystal structure reveals implications for its membrane-perforating function.  Journal of Molecular Biology. 2011 Nov 4 , 413 (4):804-814.
  6. Karanicolas J., Com J. E., Chen I., Joachimiak L. A., Dym O., Peck S. H., Albeck S., Unger T., Hu W., Liu G., Delbecq S., Montelione G. T., Spiegel C. P., Liu D. R. & Baker D. (2011). A De Novo Protein Binding Pair By Computational Design and Directed Evolution.  Molecular Cell. 2011 Apr 22 , 42 (2):250-260.
  7. Li M., Greenblatt H. M., Dym O., Albeck S., Pais A., Gunanathan C., Milstein D., Degani H. & Sussman J. (2011). Structure of estradiol metal chelate and estrogen receptor complex: The basis for designing a new class of selective estrogen receptor modulators.  Journal of Medicinal Chemistry. 2011 May 26 , 54 (10):3575-3580.
  8. Carlessi R., Levin-Salomon V., Ciprut S., Bialik S., Berissi H., Albeck S., Peleg Y. & Kimchi A. (2011). GTP binding to the ROC domain of DAP-kinase regulates its function through intramolecular signalling.  EMBO Reports. 2011 Sept , 12 (9):917-923.
  9. Khersonsky O., Röthlisberger D., Dym O., Albeck S., Jackson C. J., Baker D. & Tawfik D. S. (2010). Evolutionary optimization of computationally designed enzymes: Kemp eliminases of the ke07 series.  Journal of Molecular Biology. 2010, 396 (4):1025-1042.
  10. Unger T., Dym O., Albeck S., Jacobovitch Y., Bernehim R., Marom D., Pisanty O. & Breiman A. (2010). Crystal structure of the three FK506 binding protein domains of wheat FKBP73: evidence for a unique wFK73_2 domain.  Journal of Structural and Functional Genomics. 2010 Jun , 11 (2):113-23.
  11. Albeck S., Nordlund P. & Sussman J. L. (2010). New trends in protein expression.  Journal of Structural Biology. 2010 Oct , 172 (1):1-2.
  12. Dym O., Albeck S., Peleg Y., Schwarz A., Shakked Z., Burstein Y. & Zimhony O. (2009). Structure-Function Analysis of the Acyl Carrier Protein Synthase (AcpS) from Mycobacterium tuberculosis.  Journal of Molecular Biology. 2009 Nov 6 , 393 (4):937-950.
  13. Levin K. B., Dym O., Albeck S., Magdassi S., Keeble A. H., Kleanthous C. & Tawfik D. S. (2009). Following evolutionary paths to protein-protein interactions with high affinity and selectivity.  Nature Structural & Molecular Biology. 2009 Oct , 16 (10):1049-1055.
  14. Bab-Dinitz E., Albeck S., Peleg Y., Brumfeld V., Gottschalk K. E. & Karlish S. J. (2009). A C-terminal lobe of the β subunit of Na,K-ATPase and H,K-ATPase resembles cell adhesion molecules.  Biochemistry. 2009 Sept 15 , 48 (36):8684-8691.
  15. Manicka S., Peleg Y., Unger T., Albeck S., Dym O., Greenblatt H. A., Bourenkov G., Lamzin V., Krishnaswamy S. & Sussman J. (2008). Crystal structure of YagE, a putative DHDPS-like protein from Escherichia coli K12.  Proteins-Structure Function And Bioinformatics. 2008 Jun , 71 (4):2102-2108.
  16. Röthlisberger D., Khersonsky O., Wollacott A. M., Jiang L., DeChancie J., Betker J., Gallaher J. L., Althoff E. A., Zanghellini A., Dym O., Albeck S., Houk K. N., Tawfik D. S. & Baker D. (2008). Kemp elimination catalysts by computational enzyme design.  Nature. 2008 May 8 , 453 (7192):190-195.
  17. Albeck S., Dym O., Unger T., Snapir Z., Bercovich Z. & Kahana C. (2008). Crystallographic and biochemical studies revealing the structural basis for antizyme inhibitor function.  Protein Science. 2008 May , 17 (5):793-802.
  18. Dym O., Albeck S., Unger T., Jacobovitch J., Branzburg A., Michael Y., Frenkiel-Krispin D., Wolf S. G. & Elbaum M. (2008). Crystal structure of the Agrobacterium virulence complex VirE1-VirE2 reveals a flexible protein that can accommodate different partners.  Proceedings of the National Academy of Sciences of the United States of America. 2008 Aug 12 , 105 (32):11170-11175.
  19. Graslund S., Peleg Y., Albeck S., Unger T., Dym O., Prilusky J. & Sussman J. L. (2008). Protein production and purification.  Nature Methods. 2008 Feb , 5 (2):135-146.
  20. Liberman N., Dym O., Unger T., Albeck S., Peleg Y., Jacobovitch Y., Branzburg A., Eisenstein M., Marash L. & Kimchi A. (2008). The Crystal Structure of the C-Terminal DAP5/p97 Domain Sheds Light on the Molecular Basis for Its Processing by Caspase Cleavage.  Journal of Molecular Biology. 2008 Nov 14 , 383 (3):539-548.